Discuss of Dust Removal in Solid Agent Production Workshop

Among more than 5,000 pharmaceutical preparation manufacturers in China, there are solid

The manufacturers of pharmaceutical preparations account for more than half of the population. It can be said that solid

Body preparation is a common dosage form in my country's pharmaceutical production enterprises. for medicine

As far as the solid preparation purification workshop of the factory is concerned, the powder cattle pollution in production is the

the most prominent feature. Weighing, crushing, sieving in the production of solid dosage forms

Granulation, drying, whole granulation, blending, tableting, capsule filling, granulation

In various processes such as packaging, dust flying and diffusion are most likely to occur, especially

Mixing or cross contamination occurs by purifying the air conditioning system. for the strong

Toxic, irritating, allergic dust, the problem is even more serious.

Therefore, the drug dust emitted in the solid preparation production workshop is subject to

Effective capture, control, and removal are essential in the production of solid dosage forms.

important issues that must be addressed. In this paper, the solid preparation purification workshop powder

The links and causes of sitting are briefly analyzed, and Dingfen is proposed

Some measures for dust control and removal are provided for your reference.

Links and causes of dust generation in solid preparation purification workshop

Protect the weighing device with a curtain, the effect is better, and the solution can be better

Solve the problem of dust generation during weighing.

Granulation: Existing granulation methods usually include thousand granulation, wet granulation

There are three types of granulation and one-step granulation. Dry granulator is developed in recent years

It is a new type of pharmaceutical equipment that uses the crystal water of the material itself to directly

Then dry and extrude into granules. Thousand method granulator is a closed structure,

It can effectively prevent dust from flying during pellet operation, but it can effectively prevent dust from flying during feeding and discharging.

It is also inevitable to generate more dust during operation. Wet granulator

It is convenient, fast, less dust flying, and can be used for dense testing, but it is

There will also be a lot of dust flying when feeding.

One-step granulator integrates mixing and granulation

The drying process is operated in a clean airtight container under negative pressure

work, the powder flying is less, and the double capture system is generally used to make

There is less powder in the finished granules, but also during feeding and unloading operations

more dust

Whole granulation and blending: usually, the granules after granulation and drying are rectified.

After the granulator is granulated, it enters the next step of the mixing process. Pharmaceutical companies now generally use

The fast granulator used has less dust during the production process, but the

There will be a lot of dust flying field when feeding. If true is used in the mixing operation

The material can avoid the generation of dust when feeding, but there will be more problems when unloading.

dust is generated.

Capsule filling, tableting, granulation: blended granules

Made by capsule filling machine, tablet press and granule filling machine respectively

semi-finished products. Existing domestic commonly used capsule filling

High frozen tablet machine adopts closed structure. and equipped with a vacuum cleaner

Effectively prevent dust flying in the production process. If on the refill day

The use of vacuum feeding can minimize the generation of material during feeding.

dust.

Coating: The most efficient coating machines are currently used. usually

The air system is equipped with a vacuum cleaner, and the entire coating operation is carried out in a closed container.

Yes, the dust will not contaminate the coating room. But the general public

During the operation of the washing machine, due to the friction and tumbling between the films, a large

dust.

It can be seen from each link of the above solid preparation production that

Choose a more advanced

"GMP" required production equipment,

It can effectively prevent the generation of dust during the production process, but in each

During the feeding, discharging and equipment cleaning of the sequence, there will still be

of dust produced

3 Dust removal measures in solid preparation purification workshop

As mentioned above, in the production of solid dosage forms at various stages

It is easy to fly and spread dust in the air, especially by purifying the air conditioner to

Mixing or cross contamination occurs. Therefore, it is necessary to

Effectively capture, control and remove dust between

The measures taken for dust control and removal generally include the following four:

Physical isolation, in-situ exclusion, differential pressure isolation and fresh air full exhaust.

3.1 Physical isolation measures

In order to prevent the dust from flying and spreading, it is best to use the

Barriers to isolate, should not wait until the dust has spread throughout the room

To ventilate and dilute, the consequences of that can only be twice the result with half the effort. king of things

It is also suitable for occasions where local dust removal cannot be achieved for the dust source, for example

The dust source equipment has a special shape, and the dust catcher cannot be installed.

Physical isolation within the range.

3.1.1 Isolation method

There are generally three ways of physical isolation: in-situ isolation

Side isolation and independent isolation. In-situ isolation: dust generating equipment is located in

That is, it is isolated with a barrier in place in one corner, as shown in Figure 2(a):

Leave. If the equipment is arranged along the wall, the whole side wall is separated from the whole room.

As shown in Figure 2 (6): Independent isolation: only one device in the whole room

And the equipment is not to the side or corner, you can use physical barriers to

Enclose it to form a hut, as shown in Figure 2 (c, for example, weighing poison

Industry is an example of independent isolation.

3.1.2 Purification scheme

After physical isolation measures are taken, air purification solutions can have

The following three:

①The production process of isolation has considerable requirements on air cleanliness:

In this case, clean air can be sent to the high-altitude area to achieve a certain cleanliness level

In addition, set up a stage punching room in the high-altitude area, and the stage-punching kiln and the high-altitude area remain the same

The cleanliness is different and its pressure is higher than that of the workshop outside the high bay area.

②The production process in the isolated area does not require high air cleanliness:

In this case, an independent exhaust can be set up in the height area. outside the high-altitude area

The air in the workshop enters the high-rise area through the air vents on the physical barrier.

If the amount of occurrence is not large, it is not necessary to open the air vent, and enter through the terminal or louver.

Wind will do.

③ The isolation area requires a large amount of exhaust air: in this case, it can be

In order to send the exhaust air in the high-altitude area back to the high-altitude area after passing the raw material and passing through the pool,

That is to form a self-blessing ring. What should be specially explained here is the dedusting and passing pool device

s position.

As shown in Figure 3(a), the stand-alone generator and process equipment are placed in the same

One room is the most common way. However, this method is simple and easy to implement,

However, due to the low efficiency of this type of dust collector, the empty space of the production workshop is discharged.

The air contains a high concentration of bio-energy, so the common air outlet should be equipped with sub-high-efficiency

Or high-efficiency tools can be used.

As shown in Figure 3(6). It is a special eliminator installed on the production car of Weijin

In the detoxification room, this method can reduce noise and shadow, and avoid dust removal.

The dust collector caused secondary pollution to the workshop due to improper cleaning, but the opening of the dust collector

Stopping will affect the air balance of the room.

As shown in Figure 3(c), the entire dust chamber is used as an exhaust

The negative pressure room is provided with an air outlet with a filter on the partition wall, regardless of the

The start and stop of the dust collector will not affect the air flow balance in the southern room.